Comparison of Three Different Instruments Measuring Central Corneal Thickness before and after Laser in situ Keratomileusis_West China Medical Journal

Authors：

LIU lei , LI Jing , WANG Hujie , XU Man , KE Hongqin

Refractive Surgery Center, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430030, P. R. China;

Corresponding author：

Keywords：

A型超声角膜测厚仪; OrbscanⅡ眼前节分析仪; Pentacam眼前节分析仪; 中央角膜厚度

DOI：

CNKI: 51-1356/R.20120115.1546.016

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目的　对比A型超声角膜测厚仪、OrbscanⅡ眼前节分析仪和Pentacam眼前节分析仪测量准分子激光原位角膜磨镶术（LASIK）前后中央角膜厚度的差异。方法　 2010年10月－2011年3月，分别使用A型超声角膜测厚仪、OrbscanⅡ和Pentacam眼前节分析仪测量137例（274只眼）近视患者LASIK前后中央角膜厚度，并对测量结果进行配对t检验和Pearson相关性分析。结果　 LASIK术前A型超声、OrbscanⅡ和Pentacam测量值分别为（526.6 ± 34.1）、（516.6 ± 34.2）、（539.8 ± 31.5） μm，Pentacam测量值较A型超声和OrbscanⅡ测量值高，差异有统计学意义（P＜0.05），而A型超声和OrbscanⅡ测量值之间差异无统计学意义（P＞0.05）；LASIK术后6个月A型超声、OrbscanⅡ和Pentacam测量值分别为（448.2 ± 48.5）、（391.9 ± 58.5）、（451.5 ± 46.4） μm，LASIK术后A型超声和Pentacam测量值无差异（P＞0.05），而OrbscanⅡ测量值较A型超声和Pentacam低；Pearson相关分析显示，LASIK术后Pentacam和A型超声CCT测量值呈高度相关（P＜0.05）。结论　 3种仪器的中央角膜厚度测量值不可互换，LASIK术后A型超声和Pentacam量值较为准确。
Objective　 To compare the difference in measurements of central corneal thickness (CCT) using A-scan, OrbscanⅡand Pentacam before and after laser in situ keratomileusis (LASIK). Methods　 Between October 2010 and March 2011, the CCT of 137 patients (274 eyes) were measured by A-scan, OrbscanⅡ and Pentacam, and the results were analyzed by paired t-tests and Pearson correlation. Results　 Before LASIK, the values of CCT measured by A-scan, OrbscanⅡ and Pentacam were (526.6 ± 34.1), (516.6 ± 34.2), and (539.8 ± 31.5) μm respectively; paired t-tests showed the CCT values obtained with Pentacam were significantly higher than those with other methods (P＜0.05), but there were no statistical significant differences between OrbscanⅡand Pentacam measurements (P＞0.05). Six months after LASIK, the values of CCT measured by A-scan, OrbscanⅡand Pentacam was (448.2 ± 48.5), (391.9 ± 58.5), and (451.5 ± 46.4) μm respectively; the CCT values obtained with A-scan and Pentacam didn’t differ much from each other (P＞0.05), and the CCT values obtained with OrbscanⅡwere lower than those obtained with A-scan and Pentacam. There was a high correlation between A-scan and Pentacam measurements. Conclusion　 The these methods measuring CCT could not be used interchangeably, and A-scan and Pentacam after LASIK were more precise than OrbscanⅡ.

Citation： LIU lei,LI Jing,WANG Hujie,XU Man,KE Hongqin. Comparison of Three Different Instruments Measuring Central Corneal Thickness before and after Laser in situ Keratomileusis. West China Medical Journal, 2012, 27(1): 73-75. doi: CNKI: 51-1356/R.20120115.1546.016 Copy

1.	王娟, 李雪非, 张俊珠, 等. LASIK术后角膜基质床及全角膜厚度的变化及相关因素分析[J]. 国际眼科杂志, 2009, 9(10): 1986-1988.
2.	Iskander NG, Anderson Penno E, Peters NT, et al. Accuracy of Orbscan pachmetry measurement and DHG ultrasound pachymetry in primary laser in situ keratomileusis and LASIK enhancement procedures [J]. J Cataract Refract Surg, 2001, 27(5): 681-685.
3.	Rainer G, Petternel V, Findl O, et al. Comparison of ultrasound pachymetry and partial coherence interferometry in the measurement of central corneal thickness [J]. J Cataract Refract Surg,.
4.	刘祖国, 谢玉环, 张梅. 正常人角膜前后表面地形及全角膜厚度的研究[J]. 中华眼科杂志, 2001, 37(2): 125-128.
5.	杜之渝. Orbscan角膜地形图系统测量误差的分析[J]. 中华眼科杂志，2003, 39(1): 36-40.
6.	庞辰久, 宋晓虹, 王丽娅, 等. 不同方法测量近视眼准分子激光原位角膜磨镶术前后角膜厚度的变化[J]. 眼视光学杂志, 2009, 11(2): 138-145.
7.	Rosa N, Lanza M, Borrelli M, et al. Comparison of central corneal thickness measured with Orbscan and Pentacam[J]. J Refract Surg, 2007, 23(9): 895-899.
8.	Kim SW, Byun YJ, Kim EK, et al. Central corneal thickness measurements in unoperated eyes and eyes after PRK for myopia using Pentacam, Orbscan II, and ultrasonic pachymetry[J]. J Refract Surg, 2007, 23(9): 888-894.
9.	李坤, 陆蓓, 崇晓霞, 等. 麻醉剂和泪膜对健康人角膜厚度的影响[J]. 眼视光学杂志, 2004, 6(4): 244-248.
10.	卢敏, 叶向彧. Pentacam、Orbscan Ⅱ及A超测量中央角膜厚度的比较[J]. 眼科新进展, 2010, 30(7): 673-678.
11.	郑秀华, 陈元芝, 葛金玲, 等. Pentacam三维眼前节分析仪测量近视眼角膜厚度的可靠性分析[J]. 国际眼科杂志, 2010, 10(9): 1745-1747.
12.	陈长喜, 李建军, 游启生, 等. Pentacam眼前节分析仪测量中央角膜厚度的研究[J]. 眼科, 2009, 18(6): 418-420.
13.	贾丽, 李金科, 张超, 等. Pentacam测量近视眼角膜厚度和前房深度[J]. 国际眼科杂志, 2011, 11(1): 148-149.
14.	, 28(12): 2142-2145.

1. 　王娟, 李雪非, 张俊珠, 等. LASIK术后角膜基质床及全角膜厚度的变化及相关因素分析[J]. 国际眼科杂志, 2009, 9(10): 1986-1988.
2. 　Iskander NG, Anderson Penno E, Peters NT, et al. Accuracy of Orbscan pachmetry measurement and DHG ultrasound pachymetry in primary laser in situ keratomileusis and LASIK enhancement procedures [J]. J Cataract Refract Surg, 2001, 27(5): 681-685.
3. 　Rainer G, Petternel V, Findl O, et al. Comparison of ultrasound pachymetry and partial coherence interferometry in the measurement of central corneal thickness [J]. J Cataract Refract Surg,.
4. 　刘祖国, 谢玉环, 张梅. 正常人角膜前后表面地形及全角膜厚度的研究[J]. 中华眼科杂志, 2001, 37(2): 125-128.
5. 　杜之渝. Orbscan角膜地形图系统测量误差的分析[J]. 中华眼科杂志，2003, 39(1): 36-40.
6. 　庞辰久, 宋晓虹, 王丽娅, 等. 不同方法测量近视眼准分子激光原位角膜磨镶术前后角膜厚度的变化[J]. 眼视光学杂志, 2009, 11(2): 138-145.
7. 　Rosa N, Lanza M, Borrelli M, et al. Comparison of central corneal thickness measured with Orbscan and Pentacam[J]. J Refract Surg, 2007, 23(9): 895-899.
8. 　Kim SW, Byun YJ, Kim EK, et al. Central corneal thickness measurements in unoperated eyes and eyes after PRK for myopia using Pentacam, Orbscan II, and ultrasonic pachymetry[J]. J Refract Surg, 2007, 23(9): 888-894.
9. 　李坤, 陆蓓, 崇晓霞, 等. 麻醉剂和泪膜对健康人角膜厚度的影响[J]. 眼视光学杂志, 2004, 6(4): 244-248.
10. 　卢敏, 叶向彧. Pentacam、Orbscan Ⅱ及A超测量中央角膜厚度的比较[J]. 眼科新进展, 2010, 30(7): 673-678.
11. 　郑秀华, 陈元芝, 葛金玲, 等. Pentacam三维眼前节分析仪测量近视眼角膜厚度的可靠性分析[J]. 国际眼科杂志, 2010, 10(9): 1745-1747.
12. 　陈长喜, 李建军, 游启生, 等. Pentacam眼前节分析仪测量中央角膜厚度的研究[J]. 眼科, 2009, 18(6): 418-420.
13. 　贾丽, 李金科, 张超, 等. Pentacam测量近视眼角膜厚度和前房深度[J]. 国际眼科杂志, 2011, 11(1): 148-149.
14. , 28(12): 2142-2145.

West China Medical Journal

Comparison of Three Different Instruments Measuring Central Corneal Thickness before and after Laser in situ Keratomileusis

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